Injectable medicines influence appetite and blood-sugar pathways.
Time: Long-term treatment
Cost: Often high
Injectable medicines influence appetite and blood-sugar pathways.
Time: Long-term treatment
Cost: Often high
Dose escalation, monitoring and ongoing access are important.
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These medicines can be beneficial and appropriate for some people, but they are prescription treatments with recognised risks, monitoring needs and practical considerations. This information supports informed decisions and does not replace individual medical advice.
The MHRA strengthened warnings for GLP-1 and dual GLP-1/GIP medicines following rare severe cases of acute pancreatitis, including necrotising and fatal cases. Severe, persistent abdominal pain—sometimes radiating to the back, with or without nausea or vomiting—requires urgent medical attention.
Read the official MHRA warningThe MHRA updated semaglutide information to include a very rare risk of non-arteritic anterior ischaemic optic neuropathy (NAION), which can cause sudden, painless deterioration or loss of vision, usually in one eye. Sudden or rapidly worsening vision requires urgent assessment.
Read the official MHRA eye-safety updateGLP-1 medicines slow stomach emptying. The MHRA advises patients to tell the healthcare team before surgery or deep sedation because anaesthetic instructions or techniques may need to be adjusted. Prescribed treatment should not be stopped without medical advice.
The MHRA says GLP-1 medicines should not be used during pregnancy, while trying to become pregnant or while breastfeeding. People using oral contraception with Mounjaro should discuss additional or alternative contraception after starting treatment and following dose increases.
The Yellow Card Scheme helps regulators identify possible safety signals. A report may involve a serious outcome, but a report alone does not prove that a medicine caused the event. Regulators assess reports alongside clinical and exposure data.
The MHRA warns against illegal or falsified weight-loss medicines sold online. Such products may contain incorrect ingredients, wrong strengths or unsafe contaminants.
These warnings do not mean every patient will experience these problems or that the medicines are unsuitable for everyone. They mean that people deserve proper assessment, genuine medicines, appropriate monitoring and a clear discussion of benefits and risks before treatment starts.
Substantial average weight loss in eligible patients.
GI side effects, contraindications, lean-mass loss, cost and regain after stopping.
Three programme payments rather than an indefinite weight-loss subscription.
No permanent logging or macro calculation in the core programme.
The protected programme focuses first on weight-management education and mindset.
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